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Document 2488
DOCN M94A2488
TI Trends in urethritis incidence among HIV-infected homosexual men in the
SEROCO French cohort.
DT 9412
AU Meyer L; Creusvaux H; INSERM U292, France.
SO Int Conf AIDS. 1994 Aug 7-12;10(1):292 (abstract no. PC0093). Unique
Identifier : AIDSLINE ICA10/94370087
AB OBJECTIVE: To study trends in urethritis incidence among HIV-infected
homosexual men in a French multicentric cohort (SEROCO) 1988-1992.
METHODS: Since 1988, 1036 men with known date of infection or with a
first positive test in the 12 months before recruitment were included.
Medical and sexual behaviour history was recorded at each follow-up
visit. Sexual orientation was self-defined as homo (n = 471), bi (n =
216) or heterosexual (n = 349). Rates in urethritis incidence (per 100
person-years (PY)) during the follow-up were computed for each year of
observation between 1988 and 1992. RESULTS: Among homosexual men,
urethritis incidence rate during the whole follow-up was 3.4/100 PY. It
has increased from 2.1 in 1988 to 4.6/100 PY in 1991. When stratified
according to year of inclusion, data show a same pattern of increase
among those included in 1988 or in 1989. On the opposite, those included
after 1989, who tended to be younger, experienced a higher urethritis
incidence during the whole follow-up than those included before (8.2/100
PY vs 2.5, p < 0.05), which tended to decrease from 13.0 at inclusion in
1990 to 7.7/100 PY in 1991. The increase in urethritis rate observed in
the cohort can be attributed to transmission through unprotected anal
sex since a decrease in the percentage of cases of urethritis where use
of condom was systematic was observed. In 90 to 100% of cases according
to the year, HIV status of at least one of the sexual partners was
unknown or negative. In 1992 increase in incidence rate in homosexual
men was not sustained (2.4/100PY). Among bi and heterosexual men in the
cohort, urethritis incidence was lower (incidence rate during the whole
follow-up of respectively 2.8 and 1.6/100 PY) and no trend was observed.
CONCLUSION: The increasing incidence in urethritis observed between 1988
and 1991 among this French cohort of HIV-infected homosexual men is a
combination of an increase among those included in 1988-1989 and of the
recent recruitment of more at-risk men. Analysis of HIV status of the
partners and condom use shows evidence of on-going risk of HIV
transmission among the population of homosexual men. Rates in 1993 and
characteristics of men with urethritis during the follow-up are under
study.
DE Cohort Studies France/EPIDEMIOLOGY Homosexuality/*STATISTICS & NUMER
DATA Human HIV Infections/*COMPLICATIONS/EPIDEMIOLOGY/TRANSMISSION
Incidence Male Sex Behavior Urethritis/COMPLICATIONS/*EPIDEMIOLOGY
MEETING ABSTRACT MULTICENTER STUDY
SOURCE: National Library of Medicine. NOTICE: This material may be
protected by Copyright Law (Title 17, U.S.Code).